How many litters can a female roof rat produce in her lifetime?

A female roof rat is known to have a high reproductive potential, which allows her to produce multiple litters throughout her life. Generally, a female roof rat can produce anywhere from four to six litters per year, with an average of three to four litters when considering various environmental factors and the rat's overall health and living conditions.

In addition, each litter can contain up to 8-12 pups, meaning that a single female can contribute substantially to the population over her reproductive lifespan. Given these details, indicating that she can produce three to four litters in her lifetime aligns well with biological data and the typical reproductive capacity of roof rats, thus making it the correct response.